ABSTRACT
One of the most invasive malignant tumors of the cerebellum is medulloblastoma, which is also the most common malignant tumor of the brain in children. Patients with a recurrent disease following initial treatment have the most unfavorable prognosis. The most common metastasis locations are the spine, the posterior fossa, the bones, and the supratentorium. Late medulloblastoma metastasis in the supratentorial intraventricular region is uncommon. We report here a case with supratentorial seeding.
Subject(s)
Humans , Female , Child, Preschool , Supratentorial Neoplasms/secondary , Medulloblastoma/surgery , Medulloblastoma/pathology , Neoplasm Metastasis , Recurrence , Supratentorial Neoplasms/pathology , Supratentorial Neoplasms/therapy , Medulloblastoma/diagnostic imagingABSTRACT
PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.
Subject(s)
Adult , Aged , Female , Humans , Male , Young Adult , Astrocytoma/pathology , Neovascularization, Pathologic/pathology , Proto-Oncogene Proteins c-kit/metabolism , Supratentorial Neoplasms/pathology , Biomarkers, Tumor/metabolism , Vascular Endothelial Growth Factor A/metabolism , Age Distribution , Immunohistochemistry , Microvessels/pathology , Neoplasm Grading , Retrospective Studies , Statistics, NonparametricSubject(s)
Child , Female , Humans , Neuroectodermal Tumors/pathology , Supratentorial Neoplasms/pathologySubject(s)
Child , Humans , Male , Ependymoma/pathology , Supratentorial Neoplasms/pathology , Magnetic Resonance ImagingABSTRACT
Von Hippel Lindau (VHL) disease is a rare autosomal dominant condition manifested by central nervous system hemangioblastoma, retinal angiomas, cysts of pancreas, kidney and epididymis, pheochromocytomas and renal cell carcinoma. We present such a case in a 45 years old male patient.
Subject(s)
Carcinoma, Renal Cell/pathology , Hemangioblastoma/pathology , Humans , Kidney Neoplasms/pathology , Male , Middle Aged , Supratentorial Neoplasms/pathology , von Hippel-Lindau Disease/pathologyABSTRACT
De 14.386 estudios tomográficos realizados entre enero de 1989 y junio de 1992, 7.146 fueron de cerebro. Dentro de este grupo, 390 pacientes presentaron patología tumoral encefálica. De 130 pacientes se obtuvo confirmación histológica del tumor, correlacinando los datos obtenidos de acuerdo a edad, sexo y localización de la lesión y las variantes histológicas halladas
Subject(s)
Humans , Male , Female , Child, Preschool , Adolescent , Adult , Middle Aged , Brain Neoplasms/diagnosis , Cerebellar Neoplasms/diagnosis , Epidural Neoplasms/diagnosis , Infratentorial Neoplasms/diagnosis , Pituitary Neoplasms/diagnosis , Supratentorial Neoplasms/diagnosis , Tomography, X-Ray Computed , Biopsy, Needle/statistics & numerical data , Brain Neoplasms , Brain Neoplasms/pathology , Cerebellar Neoplasms , Cerebellar Neoplasms/pathology , Infratentorial Neoplasms , Infratentorial Neoplasms/pathology , Pituitary Neoplasms , Pituitary Neoplasms/pathology , Supratentorial Neoplasms/pathologyABSTRACT
Analisamos, retrospectivamente, 1.632 casos de neoplasias intracranianas, em um período de 50 anos (1931-1981), do Departamento de Patologia da Faculdade de Medicina da USP, 592 casos (36,2%) eram de indivíduos de 0 a 20 anos, grupo escolhido para este estudo. O total de craniofaringeomas nessa faixa etária foi de 21 casos (3,5%); de neoplasias de hipófise, oito (1,35%); de neoplasias da pineal, quatro (0,6%). Infiltraçöes em hipófise e pineal corresponderam a 24 casos (4,0%); näo houve nenhum caso de metástases. Descriçäo e importância destes achados e comparaçäo com os de outros autores é relatada